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Description |
Bordetella is a Gram-negative Beta-proteobacteria that colonizes the
respiratory tracts of mammals. It produces a complex array of adhesins,
aggressins and toxins that are presumed to be important in the colonisation of
its human host and in ensuring its survival and propagation. The organism also
has highly sophisticated mechanisms for regulating virulence factor expression,
in response to environmental signals or by reversible mutations. Bordetella
pertussis, the etiologic agent of whooping cough, produces numerous toxins
including Pertussis Toxin, Adenylate Cyclase Toxin, Dermonecrotic Toxin and
Tracheal Cytotoxin (Ref.1, 2 & 3).
Glutathione in Bordetella
is a tripeptide, composed of Glutamate, Cysteine and Glycine, and has numerous
important functions within the bacterial cell. This tripeptide is specifically a
thiol compound, present in the highest [...] |
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References:
1. Bordetella pertussis from functional genomics to intranasal vaccination.Locht C, Antoine R, Raze D, Mielcarek N, Hot D, Lemoine Y, Mascart F.Int J Med Microbiol. 2004 Apr; 293(7-8):583-8.2. Bordetella pertussis adenylate cyclase toxin: a versatile screening tool.Dautin N, Karimova G, Ladant D.Toxicon. 2002 Oct;40(10):1383-7.
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