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Glutathione Metabolism in B. pertussis

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Description

Bordetella is a Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. It produces a complex array of adhesins, aggressins and toxins that are presumed to be important in the colonisation of its human host and in ensuring its survival and propagation. The organism also has highly sophisticated mechanisms for regulating virulence factor expression, in response to environmental signals or by reversible mutations. Bordetella pertussis, the etiologic agent of whooping cough, produces numerous toxins including Pertussis Toxin, Adenylate Cyclase Toxin, Dermonecrotic Toxin and Tracheal Cytotoxin (Ref.1, 2 & 3).

Glutathione in Bordetella is a tripeptide, composed of Glutamate, Cysteine and Glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest [...]

References:

1.Bordetella pertussis from functional genomics to intranasal vaccination.
Locht C, Antoine R, Raze D, Mielcarek N, Hot D, Lemoine Y, Mascart F.
Int J Med Microbiol. 2004 Apr; 293(7-8):583-8.
2.Bordetella pertussis adenylate cyclase toxin: a versatile screening tool.
Dautin N, Karimova G, Ladant D.
Toxicon. 2002 Oct;40(10):1383-7.
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