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Glutathione Metabolism in B. quintana

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Description

Bartonella quintana is a fastidious, Gram-negative bacterial pathogen and the etiologic agent of the trench fever. This disease was first identified in the trenches of World War I. The bacterium lives in the gut of the body louse and is transmitted in their faeces. It enters the human body through damaged skin or through the conjunctiva of the eye. Promiscuity and dirty conditions in the trenches enable the spread of the disease. B. quintana is also responsible for a disease called Bacillary Angiomatosis and for causing Endocarditis (Ref.1 & 2). Glutathione is a small molecule found in Bartonella cell. Glutathione metabolism in B. quintana involves both the synthesis of Glutathione and its catabolism. It cannot enter most cells directly and [...]

References:

1.The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae.
Alsmark CM, Frank AC, Karlberg EO, Legault BA, Ardell DH, Canback B, Eriksson AS, Naslund AK, Handley SA, Huvet M, La Scola B, Holmberg M, Andersson SG.:
Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9716-21
2.The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae.
Alsmark CM, Frank AC, Karlberg EO, Legault BA, Ardell DH, Canback B, Eriksson AS, Naslund AK, Handley SA, Huvet M, La Scola B, Holmberg M, Andersson SG.
Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9716-21
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