About Us
Contact Us
Login to Protein Lounge!

Glutathione Metabolism in C. efficiens

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Corynebacterium efficiens is a small, generally nonmotile, Gram-positive, non-sporulating pleomorphic bacillus that enjoys widespread distribution. Corynebacteria are chemoorganotroph and aerobic, or facultatively anaerobic, exhibiting a fermentative metabolism (carbohydrates to lactic acid) under certain conditions. They are fastidious organisms, growing slowly on even an enriched medium. C. efficiens serve for the industrial production of L-Amino acids, in particular L-Glutamic acid (a million tons each year), for a long time. C. efficiens can grow at temperatures above 40 degrees Celsius and this feature is quite beneficial for its industrial use, because fermenters to be used for its cultivation need to be cooled down only to a lesser extent for heat removal (Ref.1).

Glutathione is a thiol compound, present in the highest concentration in [...]


1.Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens.
Nishio Y, Nakamura Y, Kawarabayasi Y, Usuda Y, Kimura E, Sugimoto S, Matsui K, Yamagishi A, Kikuchi H, Ikeo K, Gojobori T.
Genome Res. 2003 Jul; 13(7):1572-9.
2.High glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition.
Hultberg B, Hultberg M.
Clin Chim Acta. 2004 Nov; 349(1-2):45-52.
You can get all the details on this pathway through subscription