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Glutathione Metabolism in C. elegans

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Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. Furthermore, the Cysteine molecule has a sulfur-containing portion which gives the whole Glutathione molecule its ‘biochemical activity’. Glutathione is homeostatically controlled, both inside the cell and outside. It often attains millimolar levels inside cells, which makes it one [...]

References:

1.Large conformational changes in the catalytic cycle of glutathione synthase.
Gogos A, Shapiro L.
Structure (Camb). 2002 Dec; 10(12):1669-76.
2.[Gamma Glutamyltransferase]
Yoshikawa C, Naka K, Shimojo N, Ohkawa J.
Nippon Rinsho. 1995 May; 53(5):1162-7.
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