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Glutathione Metabolism in E. carotovora

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Description

The bacterium Erwinia carotovora is a member of the “soft-rot” group of Erwinias and is capable of causing tissue maceration and disease among a broad host range of plants, especially potato tubers held in storage (Ref.3). Glutathione metabolism in E. carotovora involves both the synthesis of Glutathione and its catabolism. Glutathione is a small molecule found in almost every cell. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. Furthermore, the Cysteine molecule has a sulfur-containing portion which gives the whole Glutathione molecule its [...]

References:

1.Overexpression of a eukaryotic glutathione reductase gene from Brassica campestris improved resistance to oxidative stress in Escherichia coli.
Yoon HS, Lee IA, Lee H, Lee BH, Jo J.
Biochem Biophys Res Commun. 2005 Jan 21; 326(3):618-23.
2.Metabolism and functions of glutathione in brain.
Dringen R.
Prog Neurobiol. 2000 Dec; 62(6):649-71
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