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Glutathione Metabolism in E. coli K-12 MG1655

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Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. It is homeostatically controlled, both inside the cell and outside and often attains millimolar levels inside cells, which makes it one of the most highly concentrated intracellular antioxidants. Glutathione exists in two forms. The antioxidant "reduced Glutathione" tripeptide is conventionally called Glutathione and abbreviated Gsh; the oxidized form is a sulfur-sulfur linked compound, known as Glutathione Disulfide or GSSG. The GSSG/Gsh ratio may be a sensitive [...]

References:

1.Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.
Sheehan D, Meade G, Foley VM, Dowd CA.
Biochem J. 2001 Nov 15; 360(Pt 1):1-16.
2.Role of glutathione in the response of Escherichia coli to osmotic stress.
Smirnova GV, Krasnykh TA, Oktyabrsky ON.
Biochemistry (Mosc). 2001 Sep; 66(9):973-8.
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