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Glutathione Metabolism in E. coli O157 EDL933

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Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. It is homeostatically controlled, both inside the cell and outside and often attains millimolar levels inside cells, which makes it one of the most highly concentrated intracellular antioxidants. Glutathione exists in two forms. The antioxidant "reduced Glutathione" tripeptide is conventionally called Glutathione and abbreviated Gsh; the oxidized form is a sulfur-sulfur linked compound, known as Glutathione Disulfide or GSSG. The GSSG/Gsh ratio may be a sensitive [...]

References:

1.Global expression of prophage genes in Escherichia coli O157:H7 strain EDL933 in response to norfloxacin.
Herold S, Siebert J, Huber A, Schmidt H.
Antimicrob Agents Chemother. 2005 Mar; 49(3):931-44.
2.Glycolytic and gluconeogenic growth of Escherichia coli O157:H7 (EDL933) and E. coli K-12 (MG1655) in the mouse intestine.
Miranda RL, Conway T, Leatham MP, Chang DE, Norris WE, Allen JH, Stevenson SJ, Laux DC, Cohen PS.
Infect Immun. 2004 Mar; 72(3):1666-76.
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