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Glutathione Metabolism in F. tularensis

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Francisella is a genus of pathogenic bacteria. The type species, F. tularensis is a rod-shaped Gram-negative bacterium and is the causative agent of tularemia or rabbit fever. The bacterium is an aerobic pleiomorphic coccobacillus, which requires oxygen for growth, is variable in shape, with basic shape between a rod and a sphere, do not move by their own power, and do not form spores. Glutathione metabolism in F. tularensis occurs within cells in two closely linked, enzymatically controlled reactions that utilize ATP and draw on nonessential amino acids as substrates. Glutathione is a tripeptide, composed of glutamate, cysteine and glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest [...]


1.Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency.
Ren X, Gao S, You D, Huang H, Liu Z, Mu Y, Liu J, Zhang Y, Yan G, Luo G, Yang T, Shen J.
Biochem J. 2001 Oct 15; 359(Pt 2):369-74
2.Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer.
Chu FF, Esworthy RS, Doroshow JH.
Free Radic Biol Med. 2004 Jun 15; 36(12):1481-95.
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