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Glutathione Metabolism in G. oxydens

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Gluconobacter oxydans is a Gram-negative bacterium belonging to the family Acetobacteraceae. It is a rod-shaped and obligately aerobic bacterium having a respiratory type of metabolism using oxygen as the terminal electron acceptor. It can grow in highly concentrated sugar solutions and at low pH values. It contains many membrane-bound dehydrogenases that are critical for the incomplete oxidation of biotechnologically important substrates.

Glutathione in G. oxydans is a tripeptide, composed of Glutamate, Cysteine and Glycine, and has numerous important functions within the cells. The tripeptide is the thiol compound, present in the highest concentration in all types of cells. During Glutathione metabolism, the laevorotatory amino acids present in the bacterium are used as precursors for ultimately synthesizing Glutathione. The L-Amino acid and [...]


1.A mutant Bacillus subtilis gamma-glutamyltranspeptidase specialized in hydrolysis activity.
Minami H, Suzuki H, Kumagai H.
FEMS Microbiol Lett. 2003 Jul 29; 224(2):169-73
2.Is serum gamma glutamyltransferase a marker of oxidative stress?
Lee DH, Blomhoff R, Jacobs DR Jr.
Free Radic Res. 2004 Jun; 38(6):535-9.
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