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Glutathione Metabolism in L. pneumophila Paris

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Legionella pneumophila is a motile, rod-shaped, Gram-negative, aerobic, bacterium, considered to be a facultative parasite. L. pneumophila is the causative agent of the Legionnaires disease, a potential fatal pneumonia. L. pneumophila Paris is an endemic strain that is predominant in France. Only strain Paris contains a Type-V Secretion System, and its Lvh Type-IV secretion system is encoded by a 36-kb region that is either carried on a multicopy plasmid or integrated into the chromosome. Numerous genes in L. pneumophila encode eukaryotic-like proteins or motifs that are predicted to modulate host cell functions to the pathogen s advantage. The genome thus reflects the history and lifestyle of L. pneumophila, a human pathogen of macrophages that co-evolved with fresh-water Amoebae (Ref.1 & 9).

Glutathione [...]


1.Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.
Cazalet C, Rusniok C, Bruggemann H, Zidane N, Magnier A, Ma L, Tichit M, Jarraud S, Bouchier C, Vandenesch F, Kunst F, Etienne J, Glaser P, Buchrieser C.:
Nat Genet. 2004 Nov; 36(11):1165-73. Epub 2004 Oct 3.
2.Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency.
Ren X, Gao S, You D, Huang H, Liu Z, Mu Y, Liu J, Zhang Y, Yan G, Luo G, Yang T, Shen J.
Biochem J. 2001 Oct 15; 359(Pt 2):369-74.
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