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Glutathione Metabolism in M. avium paratuberculosis

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Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine and has numerous important functions within the Mycobacterium avium paratuberculosis cells. M. avium paratuberculosis is a member of the MAC (Mycobacterium Avium Complex) but it differs significantly from other forms of MAC in its DNA. It is a causative organism of Johne s disease, a form of chronic Inflammatory Bowel Disease in cattle and other species, including primates (Ref.1).

Glutathione metabolism in M. avium occurs within cells in two closely linked, enzymatically controlled reactions that [...]

References:

1.Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG.
Nature. 1998 Jun 11; 393(6685):515-6.
2.High Glutathione turnover in human cell lines revealed by acivicin inhibition of gamma-glutamyltranspeptidase and the effects of thiol-reactive metals during acivicin inhibition.
Hultberg B, Hultberg M.
Clin Chim Acta. 2004 Nov; 349(1-2):45-52.
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