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Glutathione Metabolism in M. bovis

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Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine and has numerous important functions within the Mycobacterium cells. Mycobacteria are Gram-positive, non-motile, pleomorphic rods shaped bacteria related to the Actinomyces. Most Mycobacteria are found in habitats such as water or soil. However, a few are intracellular pathogens of animals and humans. Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture. M. bovis is also the progenitor for the M. [...]

References:

1.The complete genome sequence of Mycobacterium bovis.
Garnier T, Eiglmeier K, Camus JC, Medina N, Mansoor H, Pryor M, Duthoy S, Grondin S, Lacroix C, Monsempe C, Simon S, Harris B, Atkin R, Doggett J, Mayes R, Keating L, Wheeler PR, Parkhill J, Barrell BG, Cole ST, Gordon SV, Hewinson RG.
Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7877-82. Epub 2003 Jun 3.
2.Is serum gamma glutamyltransferase a marker of oxidative stress?
Lee DH, Blomhoff R, Jacobs DR Jr.
Free Radic Res. 2004 Jun; 38(6):535-9.
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