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Glutathione Metabolism in M. capsulatus

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Methylococcus capsulatus is an obligate, Gram-negative methanotroph. Methanotrophs are responsible for the oxidation of biologically generated methane and therefore help reduce the amount of greenhouse gas that is released to Earth s atmosphere. The conversion of methane to biomass by M. capsulatus has been exploited for large-scale commercial production of microbial proteins by fermentation. Thus, the bacterium plays major roles in global carbon cycles, and in particular, substantially reduces emissions of biologically generated methane to the atmosphere. M. capsulatus genome is highly specialized for a methanotrophic lifestyle, including redundant pathways, predicted to be involved in methanotrophy and duplicated genes for essential enzymes such as the methane monooxygenases (Ref.1).

Glutathione metabolism in M. capsulatus involves both the synthesis of Glutathione and its catabolism. [...]


1.Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath).
Ward N, Larsen O, Sakwa J, Bruseth L, Khouri H, Durkin AS, Dimitrov G, Jiang L, Scanlan D, Utterback T, Feldblyum TV, Fraser CM, Lillehaug JR, Eisen JA et al.
PLoS Biol. 2004 Oct; 2(10):e303.
2.A mutant Bacillus subtilis gamma-glutamyltranspeptidase specialized in hydrolysis activity.
Minami H, Suzuki H, Kumagai H.
FEMS Microbiol Lett. 2003 Jul 29; 224(2):169-73
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