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Glutathione Metabolism in M. tuberculosis CDC1551

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Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine and has numerous important functions within the Mycobacterium cells. Mycobacteria are Gram-positive, non-motile, pleomorphic rods shaped bacteria related to the Actinomyces. Most Mycobacteria are found in habitats such as water or soil. However, a few are intracellular pathogens of animals and humans. Mycobacterium tuberculosis CDC1551 is hyper virulent and is responsible for outbreak of tuberculosis. This strain is not more virulent than other M. tuberculosis isolates, but it induces a more rapid and [...]


1.Mycobacterium tuberculosis CDC1551 is resistant to reactive nitrogen and oxygen intermediates in vitro.
Firmani MA, Riley LW.
Infect Immun. 2002 Jul; 70(7):3965-8.
2.Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.
Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM.
J Bacteriol. 2002 Oct; 184(19):5479-90.
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