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Glutathione Metabolism in N. europaea

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Nitrosomonas europaea is a Gram-negative obligate chemolithoautotroph, which derives all its energy and reductant for growth from the aerobic oxidation of ammonia to nitrite. The bacterium participates in the biogeochemical Nitrogen cycle in the process of nitrification (Ref.1 & 2). Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in all organisms including microorganisms like N. europaea. It is a tripeptide composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells. Being water soluble, it is found mainly in the cell cytosol and other aqueous phases of the living system. It is homeostatically controlled, both inside the cell and outside and often attains millimolar levels inside cells, which makes it one of the [...]


1.Nitrosomonas europaea expresses a nitric oxide reductase during nitrification.
Beaumont HJ, van Schooten B, Lens SI, Westerhoff HV, van Spanning RJ.
J Bacteriol. 2004 Jul; 186(13):4417-21.
2.Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea.
Chain P, Lamerdin J, Larimer F, Regala W, Lao V, Land M, Hauser L, Hooper A, Klotz M, Norton J, Sayavedra-Soto L, Arciero D, Hommes N, Whittaker M, Arp D.:
J Bacteriol. 2003 May;185(9):2759-73.
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