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Glutathione Metabolism in N. farcinica

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Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. Glutathione is homeostatically controlled, both inside the cell and outside. It often attains millimolar levels inside cells, which makes it one of the most highly concentrated intracellular antioxidants. Glutathione exists in two forms. The antioxidant "reduced Glutathione" tripeptide is conventionally called Glutathione and abbreviated Gsh; the oxidized form is a sulfur-sulfur linked compound, known as Glutathione Disulfide or GSSG.

Glutathione is synthesized from its constituent amino acids [...]


1.Is serum gamma glutamyltransferase a marker of oxidative stress?
Lee DH, Blomhoff R, Jacobs DR Jr.
Free Radic Res. 2004 Jun; 38(6):535-9.
2.Nocardia farcinica arthritis of the knee. A case report.
Audenaert E, Almafragi A, Vuylsteke M, Verdonckt C, Verdonk R.
Acta Orthop Belg. 2004 Aug; 70(4):386-8.
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