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Description |
Neisseria meningitidis is a causative agent of meningitis, and is
responsible for considerable morbidity and mortality throughout the world. Most
disease-causing N. meningitidis strains belong to Serogroups A, B and
C. Serogroup A strains are responsible for major epidemics and pandemics of
meningococcal disease, and therefore most of the morbidity and mortality
associated with this disease, and Serogroup B and C strains are responsible for
outbreaks of menigitis in the developed world. N. meningitidis resides
in its natural habitat within the nasopharyngeal tract of humans. These
meningococci are opportunistic pathogens that colonize the nasopharynges and
oropharynges of asymptomatic carriers. They occasionally gain access to the
blood, and subsequently to the cerebrospinal fluid, to cause septicaemia and
meningitis (Ref.1).
Glutathione metabolism in [...] |
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References:
1. Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, Rutherford KM, Simmonds M, Skelton J, Whitehead S, Spratt BG, Barrell BG et al.Nature 2000 Mar 30; 404(6777):502-62. A mutant Bacillus subtilis gamma-glutamyltranspeptidase specialized in hydrolysis activity.Minami H, Suzuki H, Kumagai H.FEMS Microbiol Lett. 2003 Jul 29; 224(2):169-73.
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