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Description |
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The malaria parasite Plasmodium falciparum is still a major threat to
human health in the non-industrialized world mainly due to the increasing
incidence of drug resistance. Infection with P. falciparum leads to
increased oxidative stress in red blood cells, implying that the parasite
requires efficient antioxidant and redox systems to prevent damage caused
by ROS
(Reactive Oxygen Species). P.
falciparum possess functional thioredoxin and Glutathione systems.
Thioredoxin Reductase, the first step of the Thioredoxin Redox Cycle, and
Gamma-Glutamylcysteine Synthetase, the rate-limiting step of Glutathione
synthesis, are essential for parasite survival. The mRNA levels of
Gamma-Glutamylcysteine Synthetase are elevated in parasites that are oxidatively
stressed, indicating that Glutathione plays an important antioxidant role in
P. falciparum. In addition to this antioxidant [...] |
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