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Glutathione Metabolism in P. falciparum

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The malaria parasite Plasmodium falciparum is still a major threat to human health in the non-industrialized world mainly due to the increasing incidence of drug resistance. Infection with P. falciparum leads to increased oxidative stress in red blood cells, implying that the parasite requires efficient antioxidant and redox systems to prevent damage caused by ROS (Reactive Oxygen Species). P. falciparum possess functional thioredoxin and Glutathione systems. Thioredoxin Reductase, the first step of the Thioredoxin Redox Cycle, and Gamma-Glutamylcysteine Synthetase, the rate-limiting step of Glutathione synthesis, are essential for parasite survival. The mRNA levels of Gamma-Glutamylcysteine Synthetase are elevated in parasites that are oxidatively stressed, indicating that Glutathione plays an important antioxidant role in P. falciparum. In addition to this antioxidant [...]


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