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Glutathione Metabolism in P. luminescens

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Photorhabdus is the only known terrestrial bioluminescent bacteria. Most members of the Photorhabdus are however insect pathogens that live in a strict symbiotic relationship within the digestive tract of entomopathogenic nematodes. Photorhabdus luminescens is a symbiont of nematodes and a broad-spectrum insect pathogen. It encodes a large number of adhesins, toxins, hemolysins, proteases and lipases, and contains a wide array of antibiotic synthesizing genes. These proteins likely play a role in the elimination of competitors, host colonization, invasion and bioconversion of the insect cadaver, making P. luminescens a promising model for the study of symbiosis and host-pathogen interactions (Ref.1). Glutathione metabolism in P. luminescens occurs within cells in two closely linked, enzymatically controlled reactions that utilize ATP and draw on [...]


1.The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.
Duchaud E, Rusniok C, Frangeul L, Buchrieser C, Givaudan A, Taourit S, Bocs S, Boursaux-Eude C, Chandler M, Charles JF, Dassa E, Derose R, Derzelle S, Freyssinet G, Gaudriault S, Medigue C, Lanois A, Powell K, Siguier P, Vincent R, Wingate V, Zouine M, Glaser P, Boemare N, Danchin A, Kunst F.:
Nat Biotechnol. 2003 Nov; 21(11):1307-13. Epub 2003 Oct 5.
2.Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer.
Chu FF, Esworthy RS, Doroshow JH.
Free Radic Biol Med. 2004 Jun 15; 36(12):1481-95.
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