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Glutathione Metabolism in P. marinus MIT9313

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. Glutathione is homeostatically controlled, both inside the cell and outside. It often attains millimolar levels inside cells, which makes it one of the most highly concentrated intracellular antioxidants. Glutathione exists in two forms. The antioxidant "reduced Glutathione" tripeptide is conventionally called Glutathione and abbreviated Gsh; the oxidized form is a sulfur-sulfur linked compound, known as Glutathione Disulfide or GSSG.

Glutathione is synthesized from its constituent amino acids [...]


1.Kinetic mechanism of glutathione synthetase from Arabidopsis thaliana.
Jez JM, Cahoon RE.
J Biol Chem. 2004 Oct 8; 279(41):42726-31. Epub 2004 Aug 9.
2.Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation.
Rocap G, Larimer FW, Lamerdin J, Malfatti S, Chain P, Ahlgren NA, Arellano A, Coleman M, Hauser L, Hess WR, Johnson ZI, Land M, Lindell D, Post AF, Regala W, Shah M, Shaw SL, Steglich C, Sullivan MB, Ting CS, Tolonen A, Webb EA, Zinser ER, Chisholm SW.
Nature. 2003 Aug 28; 424(6952):1042-7. Epub 2003 Aug 13.
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