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Glutathione Metabolism in P. profundum

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Photobacterium is a genus within the Family Vibrionaceae. These are primarily marine organisms, hence require sodium for growth. They may be free-living in the water, or found associated with fish. Hence, it thrives in deep in the oceans as an extremophile where water pressure is so great it can crush the bones. P. profundum is adopted as a model for piezophily (Ref.1). The key to the bacterium s survival are genes that generate Omega-3 fatty acids–the heart-healthy stuff found in fish such as Salmon and several such metabolites and enzymes present in the bacterium.

Glutathione is a tripeptide, composed of glutamate, cysteine and glycine, and has numerous important functions within the Photobacterium cell. This tripeptide is specifically a thiol compound, present in [...]


1.Life at depth: Photobacterium profundum genome sequence and expression analysis.
Vezzi A, Campanaro S, D'Angelo M, Simonato F, Vitulo N, Lauro FM, Cestaro A, Malacrida G, Simionati B, Cannata N, Romualdi C, Bartlett DH, Valle G.
Science 2005 Mar 4; 307(5714):1459-61
2.Post-translational processing of Neisseria meningitidis gamma-glutamyl aminopeptidase and its association with inner membrane facing to the cytoplasmic space.
Takahashi H, Watanabe H.
FEMS Microbiol Lett. 2004 May 1; 234(1):27-35
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