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Glutathione Metabolism in R. norvegicus

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Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione is composed of Glutamate, Cysteine and Glycine that has numerous important functions within cells. The tripeptide Glutathione is part of an integrated antioxidant system that protects cells and tissues from oxidative damage. Oxidative stress can result from exposure to excessive amounts of endogenous and exogenous electrophiles (Ref.1). Glutathione exists in two forms. The antioxidant "reduced Glutathione" tripeptide is conventionally called Glutathione and abbreviated GSH; the oxidized form is a sulfur-sulfur linked compound, known as Glutathione Disulfide or GSSG. The GSSG/GSH ratio may [...]


1.Age-related changes in the activity of antioxidant and redox enzymes in rats.
Kim HG, Hong SM, Kim SJ, Park HJ, Jung HI, Lee YY, Moon JS, Lim HW, Park EH, Lim CJ.
Mol Cells. 2003 Dec 31; 16(3):278-84.
2.Gonadotropin regulation of glutathione synthesis in the rat ovary.
Luderer U, Kavanagh TJ, White CC, Faustman EM.
Reprod Toxicol. 2001 Sep-Oct; 15(5):495-504.
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