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Glutathione Metabolism in S. avermitilis

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Streptomycetes are Gram-positive soil microorganisms that produce a wide variety of secondary metabolites, many of which have potent biological activities. They produce more than half of the known biologically active microbial products, including many commercially important antibiotics, immunosuppressive compounds, animal health products, and agrochemicals. They also produce various enzymes that are commercially and academically valuable. This vast reservoir of diverse products makes Streptomyces one of the most important industrial microbial genera. S. avermitilis produces avermectins, a series of eight distinct, but closely related, macrocyclic lactones having potent anthelmintic and insecticidal activity, which are used commercially for broad-spectrum parasite control in the field of animal health, agriculture, and human infections (Ref.1).

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It [...]


1.Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.
Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S.
Nat Biotechnol. 2003 May; 21(5):526-31. Epub 2003 Apr 14.
2.Is serum gamma glutamyltransferase a marker of oxidative stress?
Lee DH, Blomhoff R, Jacobs DR Jr.
Free Radic Res. 2004 Jun; 38(6):535-9.
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