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Glutathione Metabolism in S. cerevisiae

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Description

Glutathione (L-G-Glutamyl-L-Cysteinylglycine, GSH) is a thiol tripeptide present in most living cells, from micro-organisms to human beings. It plays numerous metabolic roles, such as bioreduction, protection against oxidative stress, detoxification of endogenous toxic metabolites and xenobiotics, transport and enzymic catalysis. Yeast can use Glutathione as an endogenous sulphur source. In the presence of sulphate, excess sulphur can be incorporated into Glutathione and later mobilized by the cells. Glutathione stored in the yeast vacuole can also serve as an alternative nitrogen source during nitrogen starvation. Cellular Glutathione is implicated in tolerance to potentially toxic metalloids in Saccharomyces cerevisiae. Also Glutathione plays a role on cellular uptake of Se and Cd. In S. cerevisiae, the CIS2 gene encodes Gamma-Glutamyl Transpeptidase, the main [...]

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