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Glutathione Metabolism in S. coelicolor

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Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. These microbes are notable for their production of pharmaceutically useful compound including anti-tumour agents, immunosupressants and over two-thirds of all natural antibiotics currently available. S. coelicolor has a unique bacteriophage resistance system, designed to ward of the temperate bacteriophage (Ref.1 & 2).

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in all organisms including microorganisms like Streptomyces. It is a tripeptide composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells. Being water soluble, it is found mainly in the cell cytosol and other aqueous phases of the living [...]


1.Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).
Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA.
Nature. 2002 May 9; 417(6885):141-7.
2.Regulation of sporulation in Streptomyces coelicolor A3(2): a checkpoint multiplex?
Chater KF.
Curr Opin Microbiol. 2001 Dec; 4(6):667-73.
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