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Glutathione Metabolism in S. enterica serovar Paratyphi A

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Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. Furthermore, the Cysteine molecule has a sulfur-containing portion which gives the whole Glutathione molecule its ‘biochemical activity’. Cysteine can also enter the Glutathione metabolism through several other metabolic pathways like Cysteine, Taurine and Hypotaurine metabolism. Glutathione is homeostatically [...]


1.Fluoroquinolone-resistant Salmonella Paratyphi A.
Adachi T, Sagara H, Hirose K, Watanabe H.
Emerg Infect Dis. 2005 Jan; 11(1):172-4.
2.Overexpression of a eukaryotic glutathione reductase gene from Brassica campestris improved resistance to oxidative stress in Escherichia coli.
Yoon HS, Lee IA, Lee H, Lee BH, Jo J.
Biochem Biophys Res Commun. 2005 Jan 21; 326(3):618-23.
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