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Glutathione Metabolism in S. enterica serovar Typhi Ty2

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Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. Furthermore, the Cysteine molecule has a sulfur-containing portion which gives the whole Glutathione molecule its ‘biochemical activity’. Cysteine can also enter the Glutathione metabolism through several other metabolic pathways like Cysteine, Taurine and Hypotaurine metabolism. Glutathione is homeostatically [...]

References:

1.Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.
Deng W, Liou SR, Plunkett G 3rd, Mayhew GF, Rose DJ, Burland V, Kodoyianni V, Schwartz DC, Blattner FR.
J Bacteriol. 2003 Apr; 185(7):2330-7.
2.O-antigen expression in Salmonella enterica serovar Typhi is regulated by nitrogen availability through RpoN-mediated transcriptional control of the rfaH gene.
Bittner M, Saldias S, Estevez C, Zaldivar M, Marolda CL, Valvano MA, Contreras I.
Microbiology. 2002 Dec; 148(Pt 12):3789-99.
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