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Glutathione Metabolism in S. flexneri 2457T

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Shigella is a Gram-negative, non-sporulating, facultative anaerobic bacterium that causes Dysentery or Shigellosis in man. Shigella is highly invasive in the colon and the rectum, and is able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. The strain S. flexneri 2457T harbors four plasmids, which remains to be completed (Ref.1 & 2). Glutathione metabolism in Shigella occurs within cells in two closely linked, enzymatically controlled reactions that utilize ATP and draw on nonessential amino acids as substrates. Glutathione is a tripeptide, composed of glutamate, cysteine and glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest concentration in all types of cells.

During Glutathione metabolism, the L-Amino [...]


1.Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T.
Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR.
Infect Immun. 2003 May; 71(5):2775-86.
2.Shigella flexneri 2a strain 2457T expresses three members of the H-NS-like protein family: characterization of the Sfh protein.
Beloin C, Deighan P, Doyle M, Dorman CJ.
Mol Genet Genomics. 2003 Oct; 270(1):66-77. Epub 2003 Aug 1.
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