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Description |
Shigella is a Gram-negative, non-sporulating, facultative anaerobic
bacterium that causes Dysentery or Shigellosis in man. Shigella is
highly invasive in the colon and the rectum, and is able to proliferate in the
host cell cytoplasm, triggering an inflammatory reaction. S. flexneri
2a strain, 301 has been recently sequenced (Ref.1 & 2). Glutathione
metabolism in Shigella occurs within cells in two closely linked,
enzymatically controlled reactions that utilize ATP and draw on nonessential
amino acids as substrates. Glutathione is a tripeptide, composed of glutamate,
cysteine and glycine, and has numerous important functions within the bacterial
cell. This tripeptide is specifically a thiol compound, present in the highest
concentration in all types of cells.
During Glutathione metabolism, the
L-Amino acid (Laevorotatory Amino acids) [...] |
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References:
1. Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T.Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR.:Infect Immun. 2003 May; 71(5):2775-86.2. Shigella flexneri 2a strain 2457T expresses three members of the H-NS-like protein family: characterization of the Sfh protein.Beloin C, Deighan P, Doyle M, Dorman CJ.Mol Genet Genomics. 2003 Oct; 270(1):66-77. Epub 2003 Aug 1.
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