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Description |
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Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor.
It is ubiquitous in animals, plants, and microorganisms, and being water soluble
is found mainly in the cell cytosol and other aqueous phases of the living
system. Glutathione is a tripeptide composed of Glutamate, Cysteine and Glycine
that has numerous important functions within cells. Glutathione is
homeostatically controlled, both inside the cell and outside. It often attains
millimolar levels inside cells, which makes it one of the most highly
concentrated intracellular antioxidants. Glutathione exists in two forms. The
antioxidant "reduced Glutathione" tripeptide is conventionally called
Glutathione and abbreviated Gsh; the oxidized form is a sulfur-sulfur linked
compound, known as Glutathione Disulfide or GSSG. The GSSG/Gsh ratio may be a
sensitive [...] |
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References:
1. Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.Capela D, Barloy-Hubler F, Gouzy J, Bothe G, Ampe F, Batut J, Boistard P, Becker A, Boutry M, Cadieu E, Dreano S, Gloux S, Godrie T, Goffeau A, Kahn D, Kiss E, Lelaure V, Masuy D, Pohl T, Portetelle D, Puhler A, Purnelle B, Ramsperger U, Renard C, Thebault P, Vandenbol M, Weidner S, Galibert F.:Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9877-822. The composite genome of the legume symbiont Sinorhizobium meliloti.Galibert F. et al.Science. 2001 Jul 27; 293(5530):668-72
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