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Glutathione Metabolism in S. pombe

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Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It has been assigned several cellular functions, including protection against oxidative damage, maintenance of a reducing cellular thiol-disulfide balance, electron donation for a number of enzymes, protection of protein sulfhydryls from irreversible oxidation, and detoxification of foreign compounds. Glutathione is synthesized enzymatically from its constituent amino acids in two consecutive reactions. GSA1 (Glutathione Synthetase or GSH2) catalyzes the second step and it occurs in two different forms in Schizosaccharomyces pombe: a homodimeric protein consisting of two identical 56-kDa subunits and a heterotetrameric protein [...]


1.A second stress-inducible glutathione S-transferase gene from Schizosaccharomyces pombe.
Cho YW, Park EH, Fuchs JA, Lim CJ.
Biochim Biophys Acta. 2002 Apr 12; 1574(3):399-402.
2.An overview on glutathione in Saccharomyces versus non-conventional yeasts.
Penninckx MJ.
FEMS Yeast Res. 2002 Aug; 2(3):295-305.
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