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Glutathione Metabolism in S. typhimurium LT2

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Description

Glutathione is a sulfhydryl (-SH) antioxidant, antitoxin, and enzyme cofactor. It is ubiquitous in animals, plants, and microorganisms, and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. Furthermore, the Cysteine molecule has a sulfur-containing portion which gives the whole Glutathione molecule its ‘biochemical activity’. Cysteine can also enter the Glutathione metabolism through several other metabolic pathways like Cysteine, Taurine and Hypotaurine metabolism. Glutathione is homeostatically [...]

References:

1.Sample sequencing of a Salmonella typhimurium LT2 lambda library: comparison to the Escherichia coli K12 genome.
Wong RM, Wong KK, Benson NR, McClelland M.
FEMS Microbiol Lett. 1999 Apr 15; 173(2):411-23.
2.Glutathione S-transferase-mediated induction of GC-->AT transitions by halomethanes in Salmonella.
DeMarini DM, Shelton ML, Warren SH, Ross TM, Shim JY, Richard AM, Pegram RA.
Environ Mol Mutagen. 1997;30(4):440-7.
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