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Glutathione Metabolism in V. cholerae

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Vibrio cholerae is a facultative anaerobic, Gram-negative, crescent-shaped, motile rod like bacterium, and the causative infectious agent of the diarrheal disease, Cholera. It colonizes the mucosal surface of the human small intestine and secretes cholera toxin (Ref.1). The toxin stimulates secretion of water and electrolytes by the cells of the small intestine, leading to the severe watery diarrhoea that is characteristic of cholera. Unlike most bacterial agents of diarrhea, V. cholerae tends to survive in aquatic environments during periods between epidemics and can give rise to dramatic outbreaks of disease.

Glutathione in V. cholerae is a tripeptide, composed of glutamate, cysteine and glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in [...]


1.DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.
Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM et al.
Nature 2000 Aug 3; 406(6795):477-83
2.Post-translational processing of Neisseria meningitidis gamma-glutamyl aminopeptidase and its association with inner membrane facing to the cytoplasmic space.
Takahashi H, Watanabe H.
FEMS Microbiol Lett. 2004 May 1; 234(1):27-35
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