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Glutathione Metabolism in V. parahaemolyticus

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Vibrio parahaemolyticus, a Gram-negative marine bacterium, is a worldwide cause of food-borne gastroenteritis. The organism is phylogenetically close to V. cholerae, the causative agent of cholera (Ref.1). This universal marine pathogen is used as a bacterial model to clarify the various physiological phenomena of its native and host environments (Ref.2).

Glutathione in V. cholerae is a tripeptide composed of Glutamate, Cysteine and Glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest concentration in all types of cells. During Glutathione metabolism, the laevorotatory amino acids present in the bacterium are used as precursors for ultimately synthesizing Glutathione, the essential tripeptide. The L-Amino acid and Glutathione are converted to L-Gamma-Glutamyl-L-Amino acid [...]


1.Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae.
Makino K, Oshima K, Kurokawa K, Yokoyama K, Uda T, Tagomori K, Iijima Y, Najima M, Nakano M, Yamashita A, Kubota Y, Kimura S, Yasunaga T, Honda T, Shinagawa H, Hattori M, Iida T.
Lancet 2003 Mar 1; 361(9359):743-9
2.Overexpression of a eukaryotic glutathione reductase gene from Brassica campestris improved resistance to oxidative stress in Escherichia coli.
Yoon HS, Lee IA, Lee H, Lee BH, Jo J.
Biochem Biophys Res Commun. 2005 Jan 21; 326(3):618-23
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