ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Glutathione Metabolism in V. parahaemolyticus

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Vibrio parahaemolyticus, a Gram-negative marine bacterium, is a worldwide cause of food-borne gastroenteritis. The organism is phylogenetically close to V. cholerae, the causative agent of cholera (Ref.1). This universal marine pathogen is used as a bacterial model to clarify the various physiological phenomena of its native and host environments (Ref.2).

Glutathione in V. cholerae is a tripeptide composed of Glutamate, Cysteine and Glycine, and has numerous important functions within the bacterial cell. This tripeptide is specifically a thiol compound, present in the highest concentration in all types of cells. During Glutathione metabolism, the laevorotatory amino acids present in the bacterium are used as precursors for ultimately synthesizing Glutathione, the essential tripeptide. The L-Amino acid and Glutathione are converted to L-Gamma-Glutamyl-L-Amino acid [...]

References:

1.Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae.
Makino K, Oshima K, Kurokawa K, Yokoyama K, Uda T, Tagomori K, Iijima Y, Najima M, Nakano M, Yamashita A, Kubota Y, Kimura S, Yasunaga T, Honda T, Shinagawa H, Hattori M, Iida T.
Lancet 2003 Mar 1; 361(9359):743-9
2.Overexpression of a eukaryotic glutathione reductase gene from Brassica campestris improved resistance to oxidative stress in Escherichia coli.
Yoon HS, Lee IA, Lee H, Lee BH, Jo J.
Biochem Biophys Res Commun. 2005 Jan 21; 326(3):618-23
You can get all the details on this pathway through subscription