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Glutathione Metabolism in V. vulnificus CMCP6

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Vibrio vulnificus is an etiologic agent for severe human infection acquired through wounds or contaminated seafood. This is a lactose-fermenting, halophilic, Gram-negative, opportunistic pathogen, is found in estuarine environments and is associated with various marine species such as plankton, shellfish (Oysters, Clams, and Crabs), and finfish (Ref.1). V. vulnificus belong to the Gamma-group of Proteobacteria, and it shares morphological and biochemical characteristics with other human Vibrio pathogens, including Vibrio cholerae and Vibrio parahaemolyticus. It is divided into three biotypes according to its different biochemical and biological properties. V. vulnificus CMCP6 is a new strain of this bacterium, classified as Biotype-3 and is the sole cause of the outbreak of invasive V. vulnificus infection that occurred in Israel in people handling [...]


1.Large conformational changes in the catalytic cycle of glutathione synthase.
Gogos A, Shapiro L.
Structure (Camb). 2002 Dec; 10(12):1669-76
2.Mechanistic studies of a novel, highly potent gold-phosphole inhibitor of human glutathione reductase.
Deponte M, Urig S, Arscott LD, Fritz-Wolf K, Reau R, Herold-Mende C, Koncarevic S, Meyer M, Davioud-Charvet E, Ballou DP, Williams CH Jr, Becker K.:
J Biol Chem. 2005 Mar 24
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