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Glutathione Metabolism in X. fastidiosa 9a5c

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Xylella fastidiosa is a Gram-negative, fastidious, xylem-limited bacterium that causes a range of economically important plant diseases. It causes citrus variegated chlorosis-a serious disease of orange trees. It is responsible for pathogenicity and virulence involving toxins, antibiotics and ion sequestration systems (Ref.1 & 2). Glutathione is a tripeptide present in Xylella sp., which is composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells. The tripeptide is the thiol compound; present in the highest concentration in all types of cells.

Glutathione metabolism in X. fastidiosa involves both the synthesis of Glutathione and its catabolism. Glutathione biosynthesis starts from an L-Amino acid, which in presence of the enzyme Gamma-Glutamyltranspeptidase forms L-Gamma-Glutamyl-L-Amino acid and L-Cysteinylglycine. Gamma-Glutamyltranspeptidase is involved in Glutathione [...]


1.Stable transformation of the Xylella fastidiosa citrus variegated chlorosis strain with oriC plasmids.
Monteiro PB, Teixeira DC, Palma RR, Garnier M, Bove JM, Renaudin J.
Appl Environ Microbiol. 2001 May; 67(5):2263-9.
2.The genome sequence of the plant pathogen Xylella fastidiosa. The Xylella fastidiosa Consortium of the Organization for Nucleotide Sequencing and Analysis.
Simpson AJ, et all.
Nature. 2000 Jul 13; 406(6792):151-7.
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