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Glutathione Metabolism in Y. pestis CO92

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Description

Yersinia sp. is responsible for disease syndromes ranging from gastroenteritis to plague. Y. pestis is categorized into three subtypes or biovars; Antiqua, Mediaevalis, and Orientalis, each associated with a major pandemic. Y. pestis strain CO92 belongs to biovar Orientalis that are responsible for the current pandemic (modern plague). Glutathione is a tripeptide present in Yersinia sp., which is composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells. The tripeptide is the thiol compound, present in the highest concentration in all types of cells.

Glutathione metabolism in Y. pestis involves both the synthesis of Glutathione and its catabolism. Glutathione biosynthesis starts from an L-Amino acid, which in presence of the enzyme Gamma-GT (Gamma-Glutamyltranspeptidase) forms L-Gamma-Glutamyl-L-Amino acid and L-Cysteinylglycine. [...]

References:

1.Autocatalytic processing of gamma-glutamyltranspeptidase.
Suzuki H, Kumagai H.
J Biol Chem. 2002 Nov 8; 277(45):43536-43. Epub 2002 Aug 31.
2.Identification of catalytic nucleophile of Escherichia coli gamma-glutamyltranspeptidase by gamma-monofluorophosphono derivative of glutamic acid: N-terminal thr-391 in small subunit is the nucleophile.
Inoue M, Hiratake J, Suzuki H, Kumagai H, Sakata K.
Biochemistry. 2000 Jul 4; 39(26):7764-71.
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