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Description |
Yersinia sp. is responsible for disease syndromes ranging from
gastroenteritis to plague. Y. pestis is categorized into three subtypes
or biovars; Antiqua, Mediaevalis, and Orientalis,
each associated with a major pandemic. Y. pestis strain CO92 belongs to
biovar Orientalis that are responsible for the current pandemic (modern plague).
Glutathione is a tripeptide present in Yersinia sp., which is composed
of Glutamate, Cysteine and Glycine, and has numerous important functions within
cells. The tripeptide is the thiol compound, present in the highest
concentration in all types of cells.
Glutathione metabolism in Y.
pestis involves both the synthesis of Glutathione and its catabolism.
Glutathione biosynthesis starts from an L-Amino acid, which in presence of the
enzyme Gamma-GT (Gamma-Glutamyltranspeptidase) forms L-Gamma-Glutamyl-L-Amino
acid and L-Cysteinylglycine. [...] |
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