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Description |
Glutathione is a tripeptide present in Yersinia sp., which is composed
of Glutamate, Cysteine and Glycine, and has numerous important functions within
cells. Yersinia sp. is responsible for disease syndromes ranging from
gastroenteritis to plague. Y. pestis is categorized into three subtypes
or biovars; Antiqua, Medievalis, and Orientalis, each
associated with a major pandemic. The strain Y. pestis KIM belongs to
biovar Mediaevalis and is associated with the second pandemic, including the
Black Death.
Glutathione metabolism in Y. pestis involves both
the synthesis of Glutathione and its catabolism. Glutathione biosynthesis starts
from an L-Amino acid, which in presence of the enzyme Gamma-GT
(Gamma-Glutamyltranspeptidase) forms L-Gamma-Glutamyl-L-Amino acid and
L-Cysteinylglycine. Gamma-GT is involved in Glutathione metabolism and catalyzes
the hydrolysis and transpeptidation of [...] |
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