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Glutathione Metabolism in Y. pestis KIM

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Description

Glutathione is a tripeptide present in Yersinia sp., which is composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells. Yersinia sp. is responsible for disease syndromes ranging from gastroenteritis to plague. Y. pestis is categorized into three subtypes or biovars; Antiqua, Medievalis, and Orientalis, each associated with a major pandemic. The strain Y. pestis KIM belongs to biovar Mediaevalis and is associated with the second pandemic, including the Black Death.

Glutathione metabolism in Y. pestis involves both the synthesis of Glutathione and its catabolism. Glutathione biosynthesis starts from an L-Amino acid, which in presence of the enzyme Gamma-GT (Gamma-Glutamyltranspeptidase) forms L-Gamma-Glutamyl-L-Amino acid and L-Cysteinylglycine. Gamma-GT is involved in Glutathione metabolism and catalyzes the hydrolysis and transpeptidation of [...]

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