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Description |
Glutathione is a tripeptide present in Yersinia sp., which is composed
of Glutamate, Cysteine and Glycine, and has numerous important functions within
cells. Yersinia sp. is responsible for disease syndromes
ranging from gastroenteritis to plague. Y. pestis is categorized into
three subtypes or biovars; Antiqua, Mediaevalis, and
Orientalis, each associated with a major pandemic.
Glutathione
metabolism in Y. pestis involves both the synthesis of Glutathione and
its catabolism. Glutathione biosynthesis starts from an L-Amino acid, from which
L-Gamma-Glutamyl-L-Amino acid and L-Cysteinylglycine is formed inside the cell.
PepN (Aminopeptidase-N) catalyzes the reaction in which, L-Cysteineglycine
produces Glycine and the product participates in Cyanoamino acid metabolism. The
reaction involves release of an N-terminal Amino acid, Xaa-|-Yaa- from a
peptide, amide or arylamide. Xaa [...] |
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