Quantcast
ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Glutathione Metabolism in Y. pestis Mediaevails

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

Glutathione is a tripeptide present in Yersinia sp., which is composed of Glutamate, Cysteine and Glycine, and has numerous important functions within cells. Yersinia sp. is responsible for disease syndromes ranging from gastroenteritis to plague. Y. pestis is categorized into three subtypes or biovars; Antiqua, Mediaevalis, and Orientalis, each associated with a major pandemic.

Glutathione metabolism in Y. pestis involves both the synthesis of Glutathione and its catabolism. Glutathione biosynthesis starts from an L-Amino acid, from which L-Gamma-Glutamyl-L-Amino acid and L-Cysteinylglycine is formed inside the cell. PepN (Aminopeptidase-N) catalyzes the reaction in which, L-Cysteineglycine produces Glycine and the product participates in Cyanoamino acid metabolism. The reaction involves release of an N-terminal Amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa [...]

References:

1.Glutathione: a review on biotechnological production.
Li Y, Wei G, Chen J.
Appl Microbiol Biotechnol. 2004 Dec; 66(3):233-42.
2.Overexpression of a eukaryotic glutathione reductase gene from Brassica campestris improved resistance to oxidative stress in Escherichia coli.
Yoon HS, Lee IA, Lee H, Lee BH, Jo J.
Biochem Biophys Res Commun. 2005 Jan 21; 326(3):618-23.
You can get all the details on this pathway through subscription