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Glutathione Metabolism in Y. pseudotuberculosis

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Description

Yersinia sp. is responsible for disease syndromes ranging from gastroenteritis to plague. Y. pestis is categorized into three subtypes or biovars; Antiqua, Mediaevalis, and Orientalis, each associated with a major pandemic. Yersinia pseudotuberculosis is the least common of the three main Yersinia species to cause infections in humans. It is primarily a zoonotic infection with variable hosts, including domestic and sylvatic animals. The condition has been associated with food-borne infection, including a few outbreaks. The organism primarily leads to a gastroenteritis (diarrheal component uncharacteristic) characterized by a self-limited mesenteric lymphadenitis mimicking appendicitis. Postinfectious complications include erythema nodosum and reactive arthritis. Thus, a major triad for infection with this organism includes fever, abdominal pain, and rash. Rarely, it has been associated [...]

References:

1.Autocatalytic processing of gamma-glutamyltranspeptidase.
Suzuki H, Kumagai H.
J Biol Chem. 2002 Nov 8; 277(45):43536-43. Epub 2002 Aug 31.
2.Identification of catalytic nucleophile of Escherichia coli gamma-glutamyltranspeptidase by gamma-monofluorophosphono derivative of glutamic acid: N-terminal thr-391 in small subunit is the nucleophile.
Inoue M, Hiratake J, Suzuki H, Kumagai H, Sakata K.
Biochemistry. 2000 Jul 4; 39(26):7764-71.
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