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Glutathione Metabolism in Z. mobilis

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Description

Zymomonas mobilis is an ethanologenic microorganism used for the production of fuel ethanol (Ref.1). Glutathione metabolism in Z. mobilis involves both the synthesis of Glutathione and its catabolism. Glutathione is a small molecule found in almost every cell. It cannot enter most cells directly and therefore must be made available inside the cell from its three constituent amino acids: Glycine, Glutamate and Cysteine. The rate at which Glutathione can be made depends on the availability of Cysteine, which is relatively scarce in foodstuffs. Furthermore, the Cysteine molecule has a sulfur-containing portion which gives the whole Glutathione molecule its ‘biochemical activity’, i.e. its ability to carry out the vitally important functions. Cysteine can also enter the Glutathione metabolism through several other [...]

References:

1.The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4.
Seo JS, Chong H, Park HS, Yoon KO, Jung C, Kim JJ, Hong JH, Kim H, Kim JH, Kil JI, Park CJ, Oh HM, Lee JS, Jin SJ, Um HW, Lee HJ, Oh SJ, Kim JY, Kang HL, Lee SY, Lee KJ, Kang HS.
Nat Biotechnol. 2005 Jan; 23(1):63-8. Epub 2004 Dec 12.
2.Metabolism and functions of glutathione in brain.
Dringen R.
Prog Neurobiol. 2000 Dec; 62(6):649-71
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