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Glycine and Serine Metabolism in A. marginale

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A. marginale (Anaplasma marginale) is an obligate intracellular Gram-negative bacterium. It is the most prevalent tick-borne pathogen of cattle worldwide and is endemic in tropical and subtropical regions of the world. A. marginale causes Anaplasmosis, an infectious blood disease which results in significant morbidity and mortality in cattle. A. marginale invades the red blood cells of the host animal and multiplies, causing their destruction. The presence of the parasite in the red blood cells stimulates the cattle s immune system to remove the affected cells from circulation and destroy them. This large scale destruction of red blood cells results in Anaemia, fever, weight loss, respiratory distress, abortion and often death. Although some young, infected cattle tend to recover, they become life-time [...]


1.Serologic and molecular characterization of Anaplasma species infection in farm animals and ticks from Sicily.
de la Fuente J, Torina A, Caracappa S, Tumino G, Furla R, Almazan C, Kocan KM.
Vet. Parasitol. 2005 Jul 22.
2.Structural basis for segmental gene conversion in generation of Anaplasma marginale outer membrane protein variants.
Futse JE, Brayton KA, Knowles DP Jr, Palmer GH.
Mol. Microbiol. 2005 Jul;57(1):212-21.
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