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Glycine and Serine Metabolism in C. perfringens

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Description

C. perfringens (Clostridium perfringens) is a common Gram-positive endosporeforming, non-motile, rod-shaped, anaerobic bacillus and is known to produce a variety of toxins and enzymes that are responsible for severe myonecrotic lesions. Spores survive cooking and then germinate and multiply during storage at ambient temperature, slow cooling, or inadequate re-warming. Though its natural habitats are soil and the intestinal tracts of humans and animals, it has been isolated from virtually every environment examined for its presence. C. perfringens is a human pathogen, capable of causing illness either through wound infection or food-borne intoxication (Ref.1). Alpha-toxin is regarded as the most medically important toxin produced by C. perfringens; it is the toxin primarily responsible for the prevelent disease Gas gangrene and mild Enterotoxaemia in [...]

References:

1.Fulminant massive gas gangrene caused by Clostridium perfringens.
Kuroda S, Okada Y, Mita M, Okamoto Y, Kato H, Ueyama S, Fujii I, Morita S, Yoshida Y.
Intern. Med. 2005 May;44(5):499-502.
2.Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.
Walker N, Holley J, Naylor CE, Flores-Diaz M, Alape-Giron A, Carter G, Carr FJ, Thelestam M, Keyte M, Moss DS, Basak AK, Miller J, Titball RW.
Arch. Biochem. Biophys. 2000 Dec 1;384(1):24-30.
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