E. faecalis (Enterococcus faecalis), also known as S. faecalis (Streptococcus faecalis), a Gram-positive bacterium, is a natural inhabitant of the mammalian gastrointestinal tract and is found in soil, sewage, water and food, frequently through fecal contamination. It is an opportunistic pathogen that is a major cause of urinary tract infections, Bacteremia, bloodstream infections, wound infections, and infective Endocarditis. It has become a nosocomial pathogen that is refractory to most therapeutic options (Ref.1). The involvement of D- and L-Amino acid metabolism like L-Serine, L-Threonine and Glycine plays a major role in cell sustenance, generation of several essential compounds, intact protein synthesis, and pathogenesis in E. faecalis (Ref.2).
In E. faecalis L-Serine serves as a building block for protein synthesis and is [...]