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Glycine and Serine Metabolism in E. faecalis

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E. faecalis (Enterococcus faecalis), also known as S. faecalis (Streptococcus faecalis), a Gram-positive bacterium, is a natural inhabitant of the mammalian gastrointestinal tract and is found in soil, sewage, water and food, frequently through fecal contamination. It is an opportunistic pathogen that is a major cause of urinary tract infections, Bacteremia, bloodstream infections, wound infections, and infective Endocarditis. It has become a nosocomial pathogen that is refractory to most therapeutic options (Ref.1). The involvement of D- and L-Amino acid metabolism like L-Serine, L-Threonine and Glycine plays a major role in cell sustenance, generation of several essential compounds, intact protein synthesis, and pathogenesis in E. faecalis (Ref.2).

In E. faecalis L-Serine serves as a building block for protein synthesis and is [...]


1.Clinical Implications of Biofilm Formation by Enterococcus faecalis in the Urinary Tract.
Seno Y, Kariyama R, Mitsuhata R, Monden K, Kumon H.
Acta. Med. Okayama. 2005 Jun;59(3):79-87.
2.Characterization of the ccpA gene of Enterococcus faecalis: identification of starvation-inducible proteins regulated by ccpA.
Leboeuf C, Leblanc L, Auffray Y, Hartke A.
J. Bacteriol. 2000 Oct;182(20):5799-806.
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