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Glycine and Serine Metabolism in H. hepaticus

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H. hepaticus (Helicobacter hepaticus) causes chronic Hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of H. pylori (Helicobacter pylori), also a recognized carcinogen. H. hepaticus have a circular chromosome encoding 1,875 proteins. A total of 938, 953, and 821 proteins have orthologs in H. pylori, C. jejuni (Campylobacter jejuni), and both pathogens, respectively. H. hepaticus lacks orthologs of most known H. pylori virulence factors, including Adhesins, the Vacuolating Cytotoxin, and almost all cag pathogenicity island proteins, but have orthologs of the C. jejuni Adhesin Peb1 and the CDT (Cytolethal Distending Toxin) (Ref.1). The Type-IV secretion system helps in establishing pathogenicity. H. hepaticus are motile and Gram-negative, curved to spiral in shape, [...]


1.Infect. Immun. 2005 Jun;73(6):3559-67.
1. Ge Z, Feng Y, Whary MT, Nambiar PR, Xu S, Ng V, Taylor NS, Fox JG.
Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice.
2.The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus.
Suerbaum S, Josenhans C, Sterzenbach T, Drescher B, Brandt P, Bell M, Droge M, Fartmann B, Fischer HP, Ge Z, Horster A, Holland R, Klein K, Konig J, Macko L, Mendz GL, Nyakatura G, Schauer DB, Shen Z, Weber J, Frosch M, Fox JG.
Proc. Natl. Acad. Sci. U S A. 2003 Jun 24;100(13):7901-6.
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