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Glycine and Serine Metabolism in H. pylori J99

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The human pathogen, H. pylori (Helicobacter pylori) present in the gastric mucosa is associated with Gastritis and is often implicated in Peptic ulceration and Mucosa-associated lymphoid tissue Lymphomas (Ref.1). The H. pylori genome is important for drug discovery and vaccine development and this is exemplified by the genome analysis of not only H. pylori Strain 26695 but also H. pylori J99. H. pylori J99 protein-coding genes (91 genes) are unique to the strain. H. pylori J99 are Gram-negative, micro-aerophilic, spiral-shaped and flagellated bacteria and mainly stimulate pathogenesis of Duodenal ulcers (Ref.2 & 3).

H. pylori utilize amino acids as the sole carbon and nitrogen energy source. It also utilizes Glucose. Amino acids like Alanine, Arginine, Asparagine, Aspartate, Glutamine, Glutamate, Proline, [...]


1.Helicobacter pylori and complex gangliosides.
Roche N, Angstrom J, Hurtig M, Larsson T, Boren T, Teneberg S.
Infect. Immun. 2004 Mar;72(3):1519-29.
2.Helicobacter pylori: current status and future prospects.
O'Mahony R, Vaira D, Holton J, Basset C.
Sci. Prog. 2004;87(Pt 4):269-96.
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