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Glycine and Serine Metabolism in R. norvegicus

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Description

Glycine and Serine are two interconvertible non-essential amino acids found abundantly in almost all cell types. They serve as active ligands for many metabolic pathways where they aid in the synthesis of other essential metabolites, such as Glycogen, Glyoxylate and Pyruvate, which are of immense importance for many cellular and biological processes. The metabolic pathway that correlates Glycine and Serine in R. norvegicus (Rattus norvegicus) has a relation with metabolism of the indispensable amino acid Threonine. Mammalian cells normally do not possess all the necessary enzymes for the transamination of Threonine, the entrance of which into some catabolic pathways represents its irrevocable loss for the purposes of protein synthesis. Oxidation of Threonine, which is critical to the development of nutritional [...]

References:

1.Threonine metabolism in isolated rat hepatocytes.
House JD, Hall BN, Brosnan JT.
Am. J. Physiol. Endocrinol. Metab. 2001 Dec;281(6):E1300-7.
2.Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats.
Scheer JB, Mackey AD, Gregory JF
J. Nutr. 2005 Feb;135(2):233-8.
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