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Glycine, Serine and Threonine Metabolism

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Organisms vary widely in their ability to metabolize amino acids. Based on metabolic requirements amino acids are grouped as essential amino acids (that must be provided in as nutrient) and non-essential amino acids (biosynthesized in adequate amounts). Except for Glycine, all amino acids occur in two possible optical isomers, called D and L. Because of the two hydrogen atoms at the Alpha-carbon, Glycine is not optically active. The L-amino acids represent the vast majority of amino acids found in proteins, whereas, D-amino acids are found in some proteins produced by exotic sea-dwelling organisms, but are abundant components of the cell walls of bacteria (Ref.1). Amino acid metabolisms are vital for the maintenance of normal nitrogen balance in an organism. The [...]


1.Serine metabolism in human pregnancy.
Kalhan SC, Gruca LL, Parimi PS, O'Brien A, Dierker L, Burkett E.
Am. J. Physiol. Endocrinol. Metab. 2003 Apr;284(4):E733-40.
2.Threonine metabolism in isolated rat hepatocytes.
House JD, Hall BN, Brosnan JT.
Am. J. Physiol. Endocrinol. Metab. 2001 Dec;281(6):E1300-7.
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