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Glycine, Serine and Threonine Metabolism in A. gossypii

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The yeast A. gossypii (Ashbya gossypii), also known as E. gossypii (Eremothecium gossypii), is a free-living hemiascomycete that utililizes amino acid metabolisms to obtain its nitrogen source. For such reason the metabolism of Glycine, Serine and Threonine is essential for the survival of A. gossypii. Yeast physiology can be either obligately aerobic or facultatively fermentative. There is no known obligately anaerobic yeast. Yeasts generally use L-Serine or L-Threonine as sole nitrogen source. (Ref.1 & 2). L-Threonine is generally synthesized from Pyruvate and L-Aspartate. The enzyme Threonine Dehydratase converts Pyruvate (from Pyruvate metabolism) to amino acids like L-Serine. SHMT (Serine Hydroxymethyltransferase) then catalyzes the cleavage of L-Serine to Glycine and 5,10-Methylene-THF (5,10-Methylenetetrahydrofolate). SHMT is the major provider of one-carbon units in [...]


1.Visualizing syntenic relationships among the hemiascomycetes with the Yeast Gene Order Browser.
Byrne KP, Wolfe KH.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D452-5.
2.Genome evolution in yeasts.
Dujon B, Sherman D, Fischer G, Durrens P, Casaregola S, Lafontaine I, De Montigny J, Marck C, Neuveglise C, Talla E, Goffard N, Frangeul L, Aigle M, Anthouard V, Babour A, Barbe V, Barnay S, Blanchin S, Beckerich JM, Beyne E, Bleykasten C, Boisrame A, Boyer J, Cattolico L, Confanioleri F, De Daruvar A, Despons L, Fabre E, Fairhead C, Ferry-Dumazet H, Groppi A, Hantraye F, Hennequin C, Jauniaux N, Joyet P, Kachouri R, Kerrest A, Koszul R, Lemaire M, Lesur I, Ma L, Muller H, Nicaud JM, Nikolski M, Oztas S, Ozier-Kalogeropoulos O, Pellenz S, Potier S, Richard GF, Straub ML, Suleau A, Swennen D, Tekaia F, Wesolowski-Louvel M, Westhof E, Wirth B, Zeniou-Meyer M, Zivanovic I, Bolotin-Fukuhara M, Thierry A, Bouchier C, Caudron B, Scarpelli C, Gaillardin C, Weissenbach J, Wincker P, Souciet JL.
Nature. 2004 Jul 1;430(6995):35-44.
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