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Glycine, Serine and Threonine Metabolism in A. tumefaciens C58 Cereon

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A. tumefaciens (Agrobacterium tumefaciens) is a plant pathogen with the unique ability to transfer a defined segment of DNA to eukaryotes, where it integrates into the eukaryotic genome. It is a Gram-negative bacterium that causes tumors commonly known as ‘Galls’ or ‘Crown Galls’ in dicots. Crown Gall is formed by inserting a small segment of DNA (known as the T-DNA, for ‘Transfer DNA’) into the plant cell, which is incorporated at a semi-random location into the plant genome. The T-DNA contains genes encoding enzymes that cause the plant to create specialized sugars which the bacteria metabolize to form Opines. Agrobacterium is an Alpha-Proteobacterium of the family Rhizobiaceae and are parasitic to the plant. A. tumefaciens C58 is the first fully [...]


1.Agrobacterium tumefaciens increases cytokinin production in plastids by modifying the biosynthetic pathway in the host plant.
Sakakibara H, Kasahara H, Ueda N, Kojima M, Takei K, Hishiyama S, Asami T, Okada K, Kamiya Y, Yamaya T, Yamaguchi S.
Proc. Natl. Acad. Sci. U S A. 2005 Jul 12;102(28):9972-7.
2.Unwounded plants elicit Agrobacterium vir gene induction and T-DNA transfer: transformed plant cells produce opines yet are tumour free.
Brencic A, Angert ER, Winans SC.
Mol. Microbiol. 2005 Sep;57(6):1522-31.
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